During the session with 2 anticoagulant administrations, an extra blood sample is taken before as well as after the second anticoagulant administration.Д«efore the first test session, 1 blood sample is taken to determine antithrombin-III (AT-III). 5min after administration of the anticoagulant) and at 1h, 4h and 8h after dialysis start. To determine antiXa, blood samples are taken from the inlet dialysis line at the dialysis start (i.e. dialysis start and halfway dialysis.ДЇor each patient, the dialyzer, the dialysis mode (hemodialysis or hemodiafiltration) and the dialysis settings (blood flow, dialysate flow and substitution flow) are those as currently used by the patient during in-centre nocturnal dialysis. Each patient is dialyzed over 480min (at midweek) with 2 different settings: anticoagulation only at the dialysis start, and anticoagulation divided over two time points, i.e. Patients are randomized over 2 study arms.

This single centre, randomized cross-over study includes twenty stable chronic nocturnal hemodialysis patients with no coagulation disorder, active inflammation or chronic cumarin-derived medication. The aim of this randomized cross-over study is to objectively quantify the number of patent fibers after nocturnal dialysis in two different settings: anticoagulation only at the dialysis start, and anticoagulation divided over two time points, i.e. For nocturnal hemodialysis, there is no hard evidence whether anticoagulation should be administered only at the dialysis start or with an extra dosing halfway the dialysis session. In standard hemodialysis of 4 hours, the anticoagulant is administered at the beginning of dialysis. In addition, there is evidence that a substantial number of fibers can become blocked before this is reflected in routinely observed parameters, or in termination of the dialysis session. To avoid clotting during extracorporeal treatment, an anticoagulant is added to the circuit, resulting in an increased risk for bleeding complications. Why Should I Register and Submit Results?.

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